Enzymes - Serratia Peptidase

Serratiopeptidase (Serratia E-15 protease, also known as serralysin, serratiapeptase, serratia peptidase, serratio peptidase, or serrapeptidase) is a proteolytic enzyme (protease) produced by enterobacterium Serratia sp.

Serratiopeptidase is an endopeptidase, having molecular weight of about 60 K Dalton. It absorbs strongly at 275-280 nm. Serratiopeptidase is a stronger caseionolytic agent than any other known alkaline or neutral protease.

The medical use of enzymes as anti-inflammatory agents goes back many years. However, according to another theory, peptidases such as trypsin may be acting not as anti-inflammatory agents but rather as accelerants of the inflammatory process, thereby shortening its duration. 12 Whatever the mechanism, many studies of proteolytic enzymes over the years have demonstrated their effectiveness in relieving pain and inflammation independently of steroids or nonsteroidal anti-inflammatory drugs (NSAIDs).

Serratiopeptidase is a proteolytic enzyme available for clinical use more than a decade. Serratiopeptidase binds to alpha -2-macroglobulin in the blood in the ratio of 1:1, which helps to mask its antigenicity but retains its enzymatic activity and is slowly, transferred to site of inflammation. Serratiopeptidase hydrolyses bradykinin, histamine and serotonin responsible for oedematic status. Serratiopeptidase reduces swelling improves microcirculation and expectoration of sputum etc. Thus it can be concluded that Serratiopeptidase has anti-inflammatory, anti-oedemic and fibrinolytic activity and acts rapidly on localized inflammation